How the Immune System Works: Includes Free Desktop Edition How the Immune System Works: Includes Free Desktop Edition How the Immune System Works is not a comprehensive textbook. It's the book thousands of students have used to help them understand what's in their big, thick, immunology texts. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. Fifteen easy to follow lectures, featuring the uniquely popular humorous style and engaging analogies developed by Dr Sompayrac, provide an introduction to the 'bigger picture', followed by practical discussion on how each of the components interacts with one another. Now featuring full-color diagrams, this book has been rigorously updated for its fourth edition to reflect today's immunology teaching and includes updated discussion of B and T cell memory, T cell activation, vaccines, immunodeficiency, and cancer. Whether you are completely new to immunology, or require a refresher, How the Immune System Works is an enjoyable way of engaging with the key concepts - you need know nothing of the workings of the immune system to benefit from this book! John Wiley & Sons, Inc 978-0-470-65729-4
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How the Immune System Works: Includes Free Desktop Edition

  • Автор: Lauren Sompayrac
  • Мягкий переплет. Крепление скрепкой или клеем
  • Издательство: John Wiley & Sons, Inc
  • Год выпуска: 2012
  • Кол. страниц: 152
  • ISBN: 978-0-470-65729-4
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How the Immune System Works is not a comprehensive textbook. It's the book thousands of students have used to help them understand what's in their big, thick, immunology texts. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. Fifteen easy to follow lectures, featuring the uniquely popular humorous style and engaging analogies developed by Dr Sompayrac, provide an introduction to the 'bigger picture', followed by practical discussion on how each of the components interacts with one another. Now featuring full-color diagrams, this book has been rigorously updated for its fourth edition to reflect today's immunology teaching and includes updated discussion of B and T cell memory, T cell activation, vaccines, immunodeficiency, and cancer. Whether you are completely new to immunology, or require a refresher, How the Immune System Works is an enjoyable way of engaging with the key concepts - you need know nothing of the workings of the immune system to benefit from this book!
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LECTURE 1
An Overview

Immunology is a diffi cult subject to study for several
reasons. First, there are lots of details, and sometimes
these details get in the way of understanding the concepts.
To get around this problem, we ’ re going to concentrate
on the big picture. It will be easy for you to fi nd the
details somewhere else. A second diffi culty in learning
immunology is that there is an exception to every rule.
Immunologists love these exceptions, because they give
clues as to how the immune system functions. But for
now, we ’ re just going to learn the rules. Oh, sure, we ’ ll
come upon exceptions from time to time, but we won ’ t
dwell on them. Our goal is to examine the immune
system, stripped to its essence. The third diffi culty in
studying immunology is that our knowledge of the
immune system is still evolving. As you ’ ll see, there are
many unanswered questions, and some of the things that
seem true today will be proven false tomorrow. I ’ ll try to
give you a feeling for the way things stand now, and from
time to time I ’ ll discuss what immunologists speculate
may be true. But keep in mind that although I ’ ll try to be
straight with you, some of the things I ’ ll tell you will
change in the future (maybe even by the time you read
this!).
I think the main reason immunology is such a tough
subject, however, is that the immune system is a “ team
effort ” that involves many different players interacting
with each other. Imagine you ’ re watching a football game
on TV, and the camera is isolated on one player, say, the
tight end. You see him run at full speed down the fi eld,
and then stop. It doesn ’ t seem to make any sense. Later,
however, you see the same play on the big screen, and
now you understand: that tight end took two defenders
with him down the fi eld, leaving the running back uncovered
to catch the pass and run for a touchdown. The
immune system is just like a football team. It ’ s a network
of players who cooperate to get things done, and just
LECTURE 1
An Overview
looking at one player doesn ’ t make much sense. You need
an overall view. That ’ s the purpose of this fi rst lecture,
which you might call “ turbo immunology. ” Here, I ’ m
going to take you on a quick tour of the immune system,
so you can get a feeling for how it all fi ts together. Then
in the next lectures, we ’ ll go back and take a closer look
at the players and their interactions.

PHYSICAL BARRIERS
Our fi rst line of defense against invaders consists of
physical barriers, and to cause real trouble, viruses, bacteria,
parasites, and fungi must fi rst penetrate these
shields. Although we tend to think of our skin as the
main barrier, the area covered by our skin is only about
two square meters. In contrast, the area covered by the
mucous membranes that line our digestive, respiratory,
and reproductive tracts measures about 400 square meters
– an area about as big as two tennis courts. The main
point here is that there is a large perimeter which must
be defended.
(…)

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Acknowledgments, vii

How to Use This Book, viii

This book is neither a comprehensive text nor an exam-review tool. It is an overview of the immune system designed to give anyone who is learning immunology a feel for how the system all fits together.

The Anytime, Anywhere Textbook, ix

LECTURE 1 An Overview, 1

The immune system is a “team effort,” involving many different players who work together to provide a powerful defense against invaders. Focusing in on one player at a time makes it hard to understand the game. Here we view the action from the grandstands to get a wide-angle picture of what the immune system is all about.

LECTURE 2 The Innate Immune System, 13

The innate immune system is a “hard-wired” defense that has evolved over millions of years to recognize pathogens that commonly infect humans. It provides a rapid and powerful defense against “everyday” invaders.

LECTURE 3 B Cells and Antibodies, 24

B cells and the antibodies they produce are part of the adaptive immune system. This defense evolves during our own lifetime to protect us against invaders that we, personally, have never encountered before.

LECTURE 4 The Magic of Antigen Presentation, 38

T cells, another weapon of the adaptive immune system, only recognize invaders which are “properly presented” by specialized antigen presenting cells. This feature keeps these important cells focused on the particular attackers which they are able to defend against.

LECTURE 5 T Cell Activation, 52

Before they can spring into action, T cells must be activated. This requirement helps ensure that only useful weapons will be mobilized.

LECTURE 6 T Cells at Work, 60

Once they have been activated, helper T cells orchestrate the immune response, and killer T cells destroy infected cells.

LECTURE 7 Secondary Lymphoid Organs and Lymphocyte Trafficking, 70

B and T lymphocytes travel through secondary lymphoid organs looking for the invaders they can defend against. Once activated, B and T cells are dispatched to those areas of the body in which they can be most useful.

LECTURE 8 Restraining the Immune System, 81

The powerful weapons of the immune system must be restrained lest they become “overexuberant.” In addition, once an invader has been defeated, the immune system must be “reset” to prepare for future attacks.

LECTURE 9 Tolerance Induction and MHC Restriction, 86

T cells must be trained to focus on appropriately presented invaders, and B and T lymphocytes must learn not to attack our own bodies.

LECTURE 10 Immunological Memory, 96

B and T cells remember invaders we have previously encountered, and respond much more quickly and effectively to a subsequent attack by the same invader.

LECTURE 11 Vaccines, 102

Vaccines are used to safely mimic the attack of an invader so that our immune system will be primed and ready for a real attack.

LECTURE 12 The Immune System Gone Wrong, 107

The immune system generally does a good job of defending us while infl icting minimal “collateral damage.” Sometimes, however, mistakes are made.

LECTURE 13 Immunodeficiency, 116

Serious disease may result when our immune system does not operate at full strength.

LECTURE 14 Cancer and the Immune System, 121

Because the immune system is set up to minimize the chance that its weapons will attack our own bodies, it is not very good at defending us against cells that have become cancerous.

LECTURE 15 A Critique of the Immune System, 128

The immune system has many strengths – and a few weaknesses.

Glossary, 133

Index, 136
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